Skip to main content
Clinician-led hormone therapy across Los Angeles · Insurance accepted · Virtual appointments
(613) 324-9141

Progesterone therapy

Progesterone in Los Angeles, and why it comes with estrogen

If you still have a uterus, progesterone is not optional. Estrogen on its own thickens the uterine lining over time and raises endometrial cancer risk, and progesterone reverses that. Prescribed for women across Los Angeles.

  • Micronized, body-identical

Why it is added

Los Angeles treatment options: protecting the uterine lining

Progesterone is not there to make estrogen work better; it is there to stop the lining thickening, and that holds for every Los Angeles patient with a uterus. Estrogen stimulates the endometrium to thicken, exactly as it did during your cycle. Without anything to oppose it, that thickening continues and the risk of endometrial hyperplasia and cancer rises with time on treatment.

Progesterone triggers the shedding or stabilising that used to happen naturally each month. Adding it returns endometrial cancer risk to the level of a woman not taking hormone therapy at all.

If you have had a hysterectomy there is no lining to protect and progesterone is not required. Some women take it anyway because of its effect on sleep, and that is a reasonable choice to discuss. Related reading: treatment options, hormone pellets and hormone replacement therapy for the rest of it. Sleep is the exception worth raising: a Los Angeles patient who no longer needs progesterone for protection may still want it for that effect.

Side effects to expect
A woman taking her capsules at home

Taking it

How your Los Angeles assessment works

  1. At night

    Micronized progesterone makes most people drowsy within an hour. Taken at bedtime that is a benefit rather than a side effect.

  2. Continuous or cyclical

    Continuous daily dosing suits most postmenopausal women. Cyclical dosing, twelve to fourteen days a month, suits some women still having periods.

  3. With food or without

    Absorption improves slightly with food, though consistency matters more than timing. Pick one habit and keep it.

  4. Flag a peanut allergy

    Micronized progesterone capsules are suspended in peanut oil. If you have that allergy, say so before anything is prescribed.

Which kind

Micronized progesterone or a synthetic progestin

Two different compounds get discussed under one heading here, and telling them apart matters for anyone in Los Angeles reading older coverage of hormone therapy. Micronized progesterone is the same molecule your body made. Synthetic progestins such as medroxyprogesterone are different compounds that act on the same receptor, and they were what the 2002 WHI trial studied.

That distinction matters when you read about breast cancer risk. Some evidence suggests micronized progesterone carries a lower signal than the synthetic progestins used in the older trials, though the data is not settled enough to promise you a difference. There is more in breast cancer and hrt, about the clinic and non hormonal options go further into it. The honest position in Los Angeles is that the evidence leans toward micronized progesterone without being settled enough to promise you a different outcome.

Breast cancer and HRT
A single dose held in the palm of a hand
2002 the trial that used synthetic progestin

Related treatments

Related Los Angeles hormone therapy options

Progesterone is almost always part of a combination. These are the other components.

All treatments

Common questions

Los Angeles hormone therapy questions, answered

Who needs it, when to take it, and what the sedative effect feels like.

Usually not. With no uterine lining to protect, the main reason for prescribing it disappears. Some women still take it because it helps them sleep, and that is a legitimate reason to discuss, but it is a choice rather than a requirement.
Micronized progesterone is metabolised into compounds that act on the same brain receptors as some sedatives. The effect is real and usually noticeable within an hour. Taken at bedtime it improves sleep, which for many women is a second benefit rather than a nuisance.
Cyclical dosing produces a monthly bleed by design. Continuous dosing usually does not, though irregular spotting is common in the first three to six months while the lining settles. Bleeding that starts after a settled period without it should always be reported.
No. Compounded progesterone creams are not FDA-approved and there is little evidence that enough is absorbed through the skin to protect the uterine lining. If you are taking estrogen and have a uterus, a cream is not a substitute for an approved oral or intrauterine route.
In many cases yes. A levonorgestrel intrauterine system delivers progestin directly to the uterine lining and provides endometrial protection alongside systemic estrogen. It also handles contraception during perimenopause, which some women find convenient.

Patient reviews

Los Angeles patients on their hormone therapy

★★★★★

I had been waking three or four times a night for two years and had been told it was just stress. The consultation actually went through my cycle history. Six weeks on a patch and I am sleeping through.

Rebecca H.
Los Angeles
★★★★★

What I wanted was someone who would talk about the risks honestly rather than sell me something. They walked through the clot data and why a patch suited me better than tablets.

Marguerite O.
Beverly Hills
★★★★★

The brain fog was the part nobody warned me about. Having a clinician tell me it was a recognized symptom and not early dementia was worth the appointment on its own.

Denise W.
Pasadena
★★★★

It took two dose changes before things settled, which they had told me upfront might happen. The three-month review was booked before I left the first appointment.

Priya N.
Los Angeles

From the blog

Los Angeles menopause guides from our clinicians

All menopause articles
A woman weighing up whether to start treatment Hormone Therapy Basics

September 14, 2026 9 min read

Is hormone therapy worth it?

What you are actually weighing up, and why the honest answer depends on three things rather than one.

Read article

Next step

Work out which progesterone route suits you in Los Angeles

Whether you still have a uterus, how you sleep, whether you need contraception and any peanut allergy all steer this decision.

Consultations are by appointment. Prescriptions are issued only where clinically appropriate.