How It Is Given
Getting Started
Most Common
The balance
Hormone therapy reduces hot flashes and night sweats more effectively than anything else available, prevents bone loss and reduces fractures. Which side dominates depends heavily on when you start. Discussed in full before anything is prescribed in Los Angeles.
What improves
Vasomotor symptoms respond to systemic estrogen better than to anything else available, so that is where a Los Angeles assessment of expected benefit begins. Vasomotor symptoms respond better to systemic estrogen than to any other treatment, and it is FDA-approved as first-line for that reason. Most women see a clear reduction within four to twelve weeks.
Bone loss is prevented and fracture rates fall. That effect is well established and is one of the few benefits that persists as a measurable population-level outcome rather than a symptom score.
Vaginal and urinary symptoms improve, sleep improves where night sweats were disrupting it, and mood and joint symptoms improve for many women, though the evidence there is less firm than for flashes and bone. Related reading: safety and risks, hot flashes and night sweats and joint and muscle pain go further into it. We say which of these is firm and which is probable, because a Los Angeles patient promised mood improvement and not getting it has been misled.
What raises risk
The single biggest factor. Starting over 60, or more than ten years past menopause, shifts the balance substantially.
Oral estrogen raises clotting factors through the liver. Transdermal has not shown that increase.
The small breast cancer signal is associated with combined therapy. Estrogen alone has not shown it.
The breast cancer association grows with years of combined use, which is why the decision is reviewed annually rather than set once.
Putting it in scale
The figure you have probably already met in Los Angeles, in a headline or a leaflet, is a relative risk quoted without its starting point. The increase in breast cancer risk with combined therapy is small in absolute terms and comparable in scale to the increase associated with drinking a couple of units of alcohol daily, or with being significantly overweight.
That comparison is not offered to dismiss it. It is offered because a relative risk quoted without an absolute baseline is close to meaningless, and most reporting of this topic omits the baseline entirely. Worth reading next: breast cancer and hrt, who should not take hrt and monitoring and follow up go further into it. A number without its baseline cannot be weighed, which is why every risk figure quoted in a Los Angeles consultation should arrive with one attached.
More on safety
Six concerns, each taken one at a time, with the actual numbers.
Common questions
What goes up, what goes down, and how the numbers change with age.
Patient reviews
I had been waking three or four times a night for two years and had been told it was just stress. The consultation actually went through my cycle history. Six weeks on a patch and I am sleeping through.
What I wanted was someone who would talk about the risks honestly rather than sell me something. They walked through the clot data and why a patch suited me better than tablets.
The brain fog was the part nobody warned me about. Having a clinician tell me it was a recognized symptom and not early dementia was worth the appointment on its own.
It took two dose changes before things settled, which they had told me upfront might happen. The three-month review was booked before I left the first appointment.
From the blog
Next step
Age, time since your last period, clot history, family breast history and blood pressure turn a general statistic into a number that applies to you.
Consultations are by appointment. Prescriptions are issued only where clinically appropriate.